TERT anticorps (AA 521-620) (Cy3)

N° du produit ABIN6983163

Cet anticorps anti-TERT est un anticorps Lapin Polyclonal détectant TERT dans WB, FACS et IF (cc). Adapté pour Humain et Souris.

Aperçu rapide pour TERT anticorps (AA 521-620) (Cy3) (ABIN6983163)

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TERT est conjugé à/à la Cy3

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-TERT anticorps (Cy3)

Épitope: AA 521-620

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TERT

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: TERT

Sujet:

Synonyms: EST2, hEST2, TCS1, Telomerase associated protein 2, Telomerase Catalytic Subunit, Telomere Reverse Transcriptase, Telomerase reverse transcriptase, TERT, TP2, TRT, TERT_HUMAN, Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2.??

Background: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].

ID gène: 7015

UniProt: O14746

Pathways: Telomere Maintenance